Dr. Ruthie Angelovici

Ruthie Angelovici
Associate Professor of Biological Sciences
371D Christopher S. Bond Life Sciences Center

PhD, 2009 Weizmann Institute of Science

Research Summary

The genetic and metabolic control of seed amino acids’ composition

Research Description

Staple crop seeds, which are a major source of amino acids (AA) for both food and feed, are deficient in several essential amino acids. Attempts to use classical breeding or transgenic approaches to increase their levels often result in poor seed quality and germination vigor. This might be due to the fact that, despite having well characterized biochemical pathways, little is known about the AA network developmental constraints, interactions, response to environmental change, and the overall contribution to plant fitness and adaptation.

My primary research aims are to uncover the metabolic and genetic mechanisms driving the AA network’s response to multiple cellular demands and to environmental changes as well as to understand the evolutionary forces and developmental constraints that shaped them. To this end, my lab is focused on dissection of the genetic architecture that underlies the natural variation of seed AA related traits across multiple species under various environmental conditions and to evaluate their evolutionary context.

To achieve these goals, we employ GWAS and classical linkage mapping combined with molecular and genetic approaches, functional genomics, and bioinformatics. My lab’s long-term goals are to be able to model the genetic and metabolic response of the AA network to different abiotic stresses.

This information will provide the basis for genetic improvement through both transgenic approaches and classical breeding programs to ensure sustainable high quality seed.

Awards and Honors

College of Arts and Science Assistant Professor of the Year Award, 2021

Arthur C. Neish Young Investigator Award, Phytochemical Society of North America 2020

Mr. & Mrs. Shouson & Yunying-Kou Jen Junior Faculty Research Award in Biology 2020

Postdoctoral Independent Career Potential Award 2015

Chair of the Plant Metabolic Engineering Gordon Research Seminar 2013

BARD Postdoctoral Fellowship (2010-2012) 2010

Selected Publications

See Google Scholar for a list of Dr. Angelovici's publications.