Postdoctoral Research Associate, Department of Biological Sciences, University of Pittsburgh
Ph.D., Plant Pathology, University of Wisconsin-Madison, USA
B.S. with distinction, Biology, Columbia College, USA
Research Summary
Mechanisms of bacterial pathogenesis shaping plant-microbe interactions
Research Description
Plants and animals exist in constant interaction with diverse microbial communities, most of which are not harmful. However, shifts in environmental conditions or host immunity can lead to pathogenic outcomes. My research focuses on understanding how host environments influence bacterial metabolism and shape the dynamics of plant-microbe interactions, with an emphasis on both pathogenic and commensal relationships.
Using the economically important Ralstonia-tomato system as a model for bacterial wilt diseases, I investigate how the xylem environment governs bacterial behavior and host resistance. This work has provided key insights into the metabolic strategies that bacteria employ during colonization and infection.
Expanding beyond plant disease, I also study Arabidopsis-Pseudomonas interactions to uncover molecular mechanisms that drive host-microbiome relationships, including factors that differentiate beneficial and opportunistic bacteria. By developing a plant model of opportunistic pathogenesis, I aim to identify bacterial signaling cascades that regulate microbial metabolism in response to host-derived cues.
My research program integrates molecular biology, microbial ecology, and plant pathology to explore how environmental and host factors shape microbial lifestyles. Understanding these interactions has broad implications for managing plant diseases, improving agricultural sustainability, and deciphering fundamental principles of host-microbe relationships.
Awards and Honors
USDA National Institute of Food and Agriculture Post-doctoral Fellowship, 2022
APS Lafayette Frederick Diversity in Mentoring Award, 2021
USDA National Institute of Food and Agriculture Predoctoral Fellowship, 2020
Science & Medicine Graduate Research Scholars Fellowship, 2019
Selected Publications
A list of Dr. Hamilton's publications is available on Google Scholar.