The human opportunistic bacterial pathogen Pseudomonas aeruginosa (PsA) is a multi-host pathogen that poses a significant threat to human and environmental health. Arabidopsis thaliana ecotypes show differential resistance to P. aeruginosa, indicating an evolved host-specific resistance. One mechanism of resistance identified in an A. thaliana mutant involves altering the abundance of extracellular plant-derived chemicals required for virulence, thereby allowing the plant to avoid detection and subsequent infection. We hypothesize that distinct metabolic profiles across ecotypes may affect the ability of P. aeruginosa to successfully infect a plant host. PsA consistently dominates microbial communities across a variety of environmental settings. The adaptability of P. aeruginosa across a wide range of environments suggests strong competitiveness, but the mechanism underlying its competitive success is not yet well understood. By leveraging its multi-host capability, we can investigate the drivers of P. aeruginosa pathogenesis in Arabidopsis, begin to draw connections to pathogenesis across organisms, and investigate the mechanisms by which P. aeruginosa outcompetes other bacteria within microbial communities.