Chiswili Yves Chabu
Assistant Professor of Biological Sciences
PhD, 2008 University of Oregon
Mechanisms of cell-cell communication during development and tumor progression
Research descriptionThe elucidation of cell-intrinsic factors promoting tumor growth has been the focus of intense research in the past several decades and has revealed important details on the molecular bases of tumor development. However, it is now clear that in addition to these factors, tumor heterogeneity and cell-cell interactions within the tumor microenvironment significantly influence tumor progression in ways we don’t fully understand. One of our laboratory interests is to understand how cell-cell signaling events are initiated, interpreted, and integrated in tumor cells to modulate tumor cells behavior. We use a Drosophila tumor model and investigate how epithelial tumor cells communicate with each other and with host cells, including immune cells, to promote tumor overgrowth and metastasis. Indeed, tumor-immune cells interactions represent one of the most important and exciting aspects of cancer biology. In addition, cellular crowding causes tumors to have distinct mechanical properties in the host tissue. We are investigating a role for mechanical cues in tumor overgrowth and metastasis.
Chabu, C., Li, D-M, Xu, T. EGFR/ARF6 regulation of Hh signalling stimulates oncogenic Ras tumour overgrowth. Nature Communications 2017. doi:10.1038/ncomms14688
Mishra-Gorur, K., Çağlayan, A., Schaffer, A.E., Chabu, C., Henegariu, O., Vonhoff, F., Akgümüş, G., Nishimura, S., Han, W., Tu, S., Baran, B., Gümüş, H., Dilber, C., Zaki, M.S., Hossni, H., Rivière, J.-B., Kayserili, H., Spencer, E.G., Rosti, R.O., Schroth, J., Per, H., Çağlar, C., Çağlar, T., Dölen, D., Baranoski, J.F., Kumandaş, S., Minja, F.J., Erson-Omay, E.Z., Mane, S.M., Lifton, R.P., Xu, T., Keshishian, H., Dobyns, W.B., Chi, N.C., Šestan, N., Louvi, A., Bilgüvar, K., Yasuno, K., Gleeson, J.G., Günel, M. Erratum to Mutations in KATNB1 Cause Complex Cerebral Malformations by Disrupting Asymmetrically Dividing Neural Progenitors[Neuron, 84, 1226-1239, 2014] (2015) Neuron, 85 (1), p. 228.
Chabu, C., Xu, T. Oncogenic Ras stimulates Eiger/TNF exocytosis to promote growth. Development 2014, 141(24):4729-39.
Honors & Awards
Selected honors and awards
Best Poster Presentation, New England Science Symposium/Harvard Medical School/Novartis Institutes for Biomedical Research 2012
Award of Excellence in Biological Sciences, Best Talk at the 81st Annual Meeting of the American Association for the Advancement of Science (AAAS) 2000
Geraldine K. Lindsay Award of Excellence in Natural Sciences -- 81st Annual Meeting of the American Association for the Advancement of Science (AAAS) 2000