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Ruthie Angelovici

Assistant Professor of Biological Sciences
PhD, 2009 Weizmann Institute of Science

Email: angelovicir@missouri.edu
Office: 371D Christopher S. Bond Life Sciences Center
Phone: 573-882-3440
Additional: Website
Headshot of Ruthie Angelovici

Research

Research summary

The genetic and metabolic control of seed amino acids’ composition

Research description

Staple crop seeds, which are a major source of amino acids (AA) for both food and feed, are deficient in several essential amino acids. Attempts to use classical breeding or transgenic approaches to increase their levels often result in poor seed quality and germination vigor. This might be due to the fact that, despite having well characterized biochemical pathways, little is known about the AA network developmental constraints, interactions, response to environmental change, and the overall contribution to plant fitness and adaptation.

My primary research aims are to uncover the metabolic and genetic mechanisms driving the AA network’s response to multiple cellular demands and to environmental changes as well as to understand the evolutionary forces and developmental constraints that shaped them. To this end, my lab is focused on dissection of the genetic architecture that underlies the natural variation of seed AA related traits across multiple species under various environmental conditions and to evaluate their evolutionary context.

To achieve these goals, we employ GWAS and classical linkage mapping combined with molecular and genetic approaches, functional genomics, and bioinformatics. My lab’s long-term goals are to be able to model the genetic and metabolic response of the AA network to different abiotic stresses.

This information will provide the basis for genetic improvement through both transgenic approaches and classical breeding programs to ensure sustainable high quality seed.

Select Publications

Select Publications

Angelovici, R., Batushansky, A., Deason, N., Gonzalez-Jorge, S., Gore, M.A., Fait, A., Dellapenna, D. Network-guided GWAS improves identification of genes affecting free amino acids (2017) Plant Physiology, 173 (1), pp. 872-886.

Gonzalez-Jorge, S., Mehrshahi, P., Magallanes-Lundback, M., Lipka, A.E., Angelovici, R., Gore, M.A., DellaPenna, D. ZEAXANTHIN EPOXIDASE activity potentiates carotenoid degradation in maturing seed (2016) Plant Physiology, 171 (3), pp. 1837-1851.

Galili G, Avin-Wittenberg T, Angelovici R, Fernie AR. The role of photosynthesis and amino acid metabolism in the energy status during seed development. Frontier In Plant Science. 2014, 5(447).

Angelovici R, Lipka A.E, Deason N, Gonzales–Jorge S, Lin H, Cepela J, Buell R, Gore M and DellaPenna D. Genome-wide analysis of branched-chain amino acid levels in Arabidopsis seed. Plant Cell. 2013, 25(12):4827-43.

Gonzalez-Jorge S, Ha SH, Magallanes-Lundback M, Gilliland LU, Zhou A, Lipka AE, Nguyen YN, Angelovici R, Lin H, Cepela J, Little H, Buell CR, Gore MA, Dellapenna D. Carotenoid cleavage dioxygenase4 is a negative regulator of β-carotene content in Arabidopsis seeds. Plant Cell. 2013, 25(12):4812-26.

Angelovici R, Fait A, Fernie AR, Galili G. A seed high-lysine trait is negatively associated with the TCA cycle and slows down Arabidopsis seed germination. New Phytol. 2011, 189(1): 148–159.

Less H*, Angelovici R*, Tzin V*, Galili G. Coordinated gene networks regulating Arabidopsis plant metabolism in response to various stresses and nutritional cues. Plant Cell. 2011, 23(4):1264-71.

Angelovici R, Galili G, Fernie A, and Fait A. Seed desiccation: a bridge between maturation and germination. Trends In Plant Sci. 2010, 15(4):211-8 (Review).

Angelovici R*, Fait A*, Zhu X, Szymanski J, Feldmesser J, Fernie AR, and Galili G. Deciphering transcriptional and metabolic networks associated with lysine metabolism during Arabidopsis seed development. Plant Physiol. 2009, 151(4):2058-2072.

Fait A*, Angelovici R*, Less H, Ohad I, Urbanczyk-Wochniak E, Fernie AR, Galili G. Arabidopsis seed development and germination is associated with temporally distinct metabolic switches. Plant Physiol. 2006 Nov; 142(3):839-54.

Honors & Awards

Selected honors and awards

Postdoctoral Independent Career Potential Award 2015

Chair of the Plant Metabolic Engineering Gordon Research Seminar 2013

BARD Postdoctoral Fellowship (2010-2012) 2010