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Lorin Milescu

Assistant Professor of Biological Sciences
PhD, 2003 SUNY Buffalo, NY

Email: milescul@missouri.edu
Office: 204 Lefevre Hall
Phone: 573-882-2870
Additional: Website
Headshot of Lorin Milescu

Research

Research summary

Biophysics and neurophysiology of voltage gated ion channels; neuronal firing mechanisms; neurobiology of respiration

Research description

We investigate how voltage-gated ion channels determine the firing activity of individual neurons, and how neurons interact to generate distinct network behaviors. We address these questions in a brain slice preparation containing the pre-Bötzinger respiratory pacemaker, using patch-clamp electrophysiology, multiphoton imaging, real-time biological-computational models, maximum likelihood algorithms, and software development.

Select Publications

Select Publications

Mishra A, Salari A, Berigan BR, Miguel KC, Amirshenava M, Robinson A, Zars BC, Lin JL, Milescu LS*, Milescu M*, and Zars T*. (2018) The Drosophila GR28B-d product is a non-specific cation channel that can be used as a novel thermogenetic tool. Scientific Reports 8(1): 901. (*Co-corresponding authors)

Navarro MA, Salari A, Milescu M, Milescu LS. (2018). Estimating kinetic mechanisms with prior knowledge II: Behavioral constraints and numerical tests. J. Gen. Physiol., DOI: 10.1085/jgp.201711912

Salari A, Navarro MA, Milescu M, Milescu LS. (2018) Estimating kinetic mechanisms with prior knowledge I: Linear parameter constraints. J. Gen. Physiol., DOI: 10.1085/jgp.201711911

Strege PR, Knutson K, Eggers SJ, Li JH, Wang F, Linden D, Szurszewski JH, Milescu L, Leiter AB, Farrugia G, and Beyder A (2017) Sodium channel NaV 1.3 is important for enterochromaffin cell excitability and serotonin release. Scientific Reports 6: 23894.

Salari A, Navarro MA, and Milescu LS (2016) Modeling the Kinetic Mechanisms of Voltage-Gated Ion Channels. In: A. Korngreen (ed) Patch-Clamp Analysis: Advanced Techniques (pp. 267-304), NY: Springer.

Salari A, Vega BS, Milescu LS, Milescu M. (2016) Molecular interactions between tarantula toxins and low-voltage-activated calcium channels. Scientific Reports, 6, art. no. 23894,

Milescu L.S. (2015) A stochastic relationship. Biophysical Journal, 108: 225-227.

Navarro MA, Hibbard JVK, Miller ME, Nivin TW, and Milescu LS (2015) 3D data mapping and real-time experiment control and visualization in brain slices. Biophys J. 109:1521-1527.

Tabak J, Tomaiuolo M, Gonzalez-Iglesias AE, Milescu LS, Bertram R (2011) Fast activating voltage- and calcium-dependent potassium (BK) conductance promotes bursting in pituitary cells: a dynamic clamp study. J. Neurosci. 31:16855-16863.

Milescu LS, Yamanishi T, Ptak K, and Smith JC (2010) Kinetic properties and functional dynamics of sodium channels during repetitive spiking in a slow pacemaker neuron. J Neurosci 30:12113-27.

Milescu LS, Bean BP, and Smith JC (2010) Isolation of somatic Na+ currents by selective inactivation of axonal channels with a voltage prepulse. J Neurosci 30:7740-8.