Assistant Research Professor of Biological Sciences
PhD, 1985 University of Keele, Staffordshire
Hormonal regulation and endocrine disruption of fetal development, with consequences to adult reproductive function and disease.
Research descriptionMy research focuses on the role of the early endocrine environment on reproductive and urogenital tract development, and on the impact of exogenous estrogens on normal development. Primary emphasis is on the role of fetal or neonatal exposure to exogenous estrogenic chemicals in the development of adult reproductive or urogenital disorders, with a particular focus on the prostate and the urethra. I use the fetal mouse prostate as a model system to study mechanisms of estrogen action during early development, and have used a primary cell culture derived from the fetal urogenital sinus to examine the effects of estrogen exposure on gene expression.
A second research interest is sources and consequences of human exposure to one specific endocrine disrupter, bisphenol A (BPA). Our recent data indicate that BPA metabolism is similar in mice, monkeys and humans, even though the routes of metabolism differ, and opens the door wider for use of the mouse as a model for human exposures. I am extending the metabolism studies with mice to establish potential vulnerabilities that might be related to human health outcomes.
Stahlhut RW, van Breemen RB, Gerona RR, Taylor JA, Welshons WV, Vom Saal FS: Comment on “Optimal exposure biomarkers for nonpersistent chemicals in environmental epidemiology”. Environmental Health Perspectives 2016, 124(4):A66.
Gerona, R.R., Pan, J., Zota, A.R., Schwartz, J.M., Friesen, M., Taylor, J.A., Hunt, P.A., Woodruff, T.J. Direct measurement of Bisphenol A (BPA), BPA glucuronide and BPA sulfate in a diverse and low-income population of pregnant women reveals high exposure, with potential implications for previous exposure estimates: A cross-sectional study (2016) Environmental Health: A Global Access Science Source, 15 (1), art. no. 131,
Vandenberg, L.N., Gerona, R.R., Kannan, K., Taylor, J.A., Van Breemen, R.B., Dickenson, C.A., Liao, C., Yuan, Y., Newbold, R.R., Padmanabhan, V., Vom Saal, F.S., Woodruff, T.J. Erratum: A round robin approach to the analysis of bisphenol a (BPA) in human blood samples (2016) Environmental Health: A Global Access Science Source, 15 (1), art. no. 126,
Kassotis CD, Alvarez DA, Taylor JA, vom Saal FS, Nagel SC, Tillitt DE: Characterization of Missouri surface waters near point sources of pollution reveals potential novel atmospheric route of exposure for bisphenol A and wastewater hormonal activity pattern. Science of the Total Environment 2015, 524-525:384-393.
Vandenberg LN, Gerona RR, Kannan K, Taylor JA, Van Breemen RB, Dickenson CA, Liao C, Yuan Y, Newbold RR, Padmanabhan V et al: A round robin approach to the analysis of bisphenol a (BPA) in human blood samples. Environmental Health: A Global Access Science Source 2014, 13(1).
Vom Saal FS, Vandevoort CA, Taylor JA, Welshons WV, Toutain PL, Hunt PA: Bisphenol A (BPA) pharmacokinetics with daily oral bolus or continuous exposure via silastic capsules in pregnant rhesus monkeys: Relevance for human exposures. Reproductive Toxicology 2014, 45:105-116.
Lathi RB, Liebert CA, Brookfield KF, Taylor JA, Vom Saal FS, Fujimoto VY, Baker VL: Conjugated bisphenol A in maternal serum in relation to miscarriage risk. Fertility and Sterility 2014, 102(1):123-128.
Hormann AM, Vom Saal FS, Nagel SC, Stahlhut RW, Moyer CL, Ellersieck MR, Welshons WV, Toutain PL, Taylor JA: Holding thermal receipt paper and eating food after using hand sanitizer results in high serum bioactive and urine total levels of bisphenol A (BPA). PLoS ONE 2014, 9(10).
Angle BM, Do RP, Ponzi D, Stahlhut RW, Drury BE, Nagel SC, Welshons WV, Besch-Williford CL, Palanza P, Parmigiani S et al: Metabolic disruption in male mice due to fetal exposure to low but not high doses of bisphenol A (BPA): Evidence for effects on body weight, food intake, adipocytes, leptin, adiponectin, insulin and glucose regulation. Reproductive Toxicology 2013, 42:256-268.
Hanna CW, Bloom MS, son WP, Kim D, Parsons PJ, Vom Saal FS, Taylor JA, Steuerwald AJ, Fujimoto VY: DNA methylation changes in whole blood is associated with exposure to the environmental contaminants, mercury, lead, cadmium and bisphenol A, in women undergoing ovarian stimulation for IVF. Human Reproduction 2012, 27(5):1401-1410.
vom Saal FS, Nagel SC, Coe BL, Angle BM, Taylor JA: The estrogenic endocrine disrupting chemical bisphenol A (BPA) and obesity. Molecular and Cellular Endocrinology 2012, 354(1-2):74-84.
Taylor JA, vom Saal FS, Welshons WV, Drury B, Rottinghaus G, Hunt PA, Toutain PL, Laffont CM: Bisphenol A in thermal paper receipts: Taylor et al. Rspond. Environmental Health Perspectives 2012, 120(1).
Taylor JA, Richter CA, Suzuki A, Watanabe H, Iguchi T, Coser KR, Shioda T, vom Saal FS: Dose-Related Estrogen Effects on Gene Expression in Fetal Mouse Prostate Mesenchymal Cells. PLoS ONE 2012, 7(10).
Do RP, Stahlhut RW, Ponzi D, vom Saal FS, Taylor JA: Non-monotonic dose effects of in utero exposure to di(2-ethylhexyl) phthalate (DEHP) on testicular and serum testosterone and anogenital distance in male mouse fetuses. Reproductive Toxicology 2012, 34(4):614-621.
Wolstenholme JT, Edwards M, Shetty SRJ, Gatewood JD, Taylor JA, Rissman EF, Connelly JJ: Gestational exposure to bisphenol a produces transgenerational changes in behaviors and gene expression. Endocrinology 2012, 153(8):3828-3838.
Schug TT, Vogel SA, Vandenberg LN, Braun JM, Hauser R, Taylor JA, Vom Saal FS, Heindel JJ: Bisphenol A. In: Dioxins and Health: Including Other Persistent Organic Pollutants and Endocrine Disruptors: Third Edition. 2012: 381-413.
Honors & Awards
Selected honors and awards
Art & Science Alumni Association Faculty Incentive Award 2005
University of Keele Postgraduate Studentship 1982
University of Keele Postgraduate Studentship 1981